原钒酸钠对大鼠心脏乳头肌收缩力的影响.doc
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原钒酸钠对大鼠心脏乳头肌收缩力的影响,本文共5页 313字6摘要 目的：初步探讨原钒酸钠对离体大鼠乳头肌张力变化的作用及其机制。方法：①正常wistar大鼠分为正常对照组，原钒酸钠组，原钒酸钠+普奈洛尔组，原钒酸钠+去甲肾上腺素组，原钒酸钠+维拉帕米组。②取大鼠乳头肌放入恒温平滑肌槽中连于张力换能器，观察原钒酸钠等各组对...
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原钒酸钠对大鼠心脏乳头肌收缩力的影响
本文共5页 313字
6
摘要 目的：初步探讨原钒酸钠对离体大鼠乳头肌张力变化的作用及其机制。
方法：①正常Wistar大鼠分为正常对照组，原钒酸钠组，原钒酸钠+普奈洛尔组，原钒酸钠+去甲肾上腺素组，原钒酸钠+维拉帕米组。②取大鼠乳头肌放入恒温平滑肌槽中连于张力换能器，观察原钒酸钠等各组对乳头肌收缩力的影响。结果：①原钒酸钠可增强大鼠乳头肌张力；②去甲肾上腺素可以增加心肌乳头肌收缩张力。原钒酸钠对去甲肾上腺素的这一作用具有协同作用；③当用普奈洛尔阻断心肌β受体后，原钒酸钠增加乳头肌张力的作用消失。结论：原钒酸钠可增强大鼠乳头肌张力，此作用与β受体有关，但与L-型钙通道无关。
关键词 原钒酸钠，乳头肌
Abstract Objective: primarily investigate the effect and mechanism of sodium orthvanadate to papillary muscle of rat in vitro . Methods: papillary muscle were taken from rat. Then incubated in tynol solution consisting of homeothermia smooth muscle sink,which was hanged under the muscular tension sensor , observing the pharmacology effects the drugs such as sodium orthvanadate ect.to the contractility force of papillary muscle Results:①the contractivity force of papillary muscle can be improved by sodium orthvanadate;②noradrenaline can also increased the contractility force of papillary muscle,which can be symphosized by sodium orthvanadate.;③ The effect of sodium orthvanadate to the tension of papillary muscle disappeared when the β-receptor was blocked by propranolol. Conclusion: The tension of papillary muscle of rat can be improved by sodium orthvanadate. which is related the β-receptor . but has no relation to L-type calcium channel .
Key words sodium orthvanadate ，papillary muscle
参 考 文 献
[1] Brichard S M, Henquin JC. The role of of vanadium in the management of diabete, Trends Pharmacol sci,1995;16(8):265~270
[2] 杜杰，艾静，杨宝峰. 原钒酸钠对2型糖尿病的降糖作用研究[J]. 中国药理学通报，2003，19（3）：322-325.
[3] 龙江，何树庄，杨宝峰 原钒酸钠的细胞毒理学实验研究 中国药理学通报 2003 年 04期
[4] 姚泰 主编 生理学第五版.北京：人民卫生出版社，2002.11 75~76
[5] 杨宝峰 主编 药理学第六版.北京：人民卫生出版社，2003.8 103~106，194~206
本文共5页 313字
6
摘要 目的：初步探讨原钒酸钠对离体大鼠乳头肌张力变化的作用及其机制。
方法：①正常Wistar大鼠分为正常对照组，原钒酸钠组，原钒酸钠+普奈洛尔组，原钒酸钠+去甲肾上腺素组，原钒酸钠+维拉帕米组。②取大鼠乳头肌放入恒温平滑肌槽中连于张力换能器，观察原钒酸钠等各组对乳头肌收缩力的影响。结果：①原钒酸钠可增强大鼠乳头肌张力；②去甲肾上腺素可以增加心肌乳头肌收缩张力。原钒酸钠对去甲肾上腺素的这一作用具有协同作用；③当用普奈洛尔阻断心肌β受体后，原钒酸钠增加乳头肌张力的作用消失。结论：原钒酸钠可增强大鼠乳头肌张力，此作用与β受体有关，但与L-型钙通道无关。
关键词 原钒酸钠，乳头肌
Abstract Objective: primarily investigate the effect and mechanism of sodium orthvanadate to papillary muscle of rat in vitro . Methods: papillary muscle were taken from rat. Then incubated in tynol solution consisting of homeothermia smooth muscle sink,which was hanged under the muscular tension sensor , observing the pharmacology effects the drugs such as sodium orthvanadate ect.to the contractility force of papillary muscle Results:①the contractivity force of papillary muscle can be improved by sodium orthvanadate;②noradrenaline can also increased the contractility force of papillary muscle,which can be symphosized by sodium orthvanadate.;③ The effect of sodium orthvanadate to the tension of papillary muscle disappeared when the β-receptor was blocked by propranolol. Conclusion: The tension of papillary muscle of rat can be improved by sodium orthvanadate. which is related the β-receptor . but has no relation to L-type calcium channel .
Key words sodium orthvanadate ，papillary muscle
参 考 文 献
[1] Brichard S M, Henquin JC. The role of of vanadium in the management of diabete, Trends Pharmacol sci,1995;16(8):265~270
[2] 杜杰，艾静，杨宝峰. 原钒酸钠对2型糖尿病的降糖作用研究[J]. 中国药理学通报，2003，19（3）：322-325.
[3] 龙江，何树庄，杨宝峰 原钒酸钠的细胞毒理学实验研究 中国药理学通报 2003 年 04期
[4] 姚泰 主编 生理学第五版.北京：人民卫生出版社，2002.11 75~76
[5] 杨宝峰 主编 药理学第六版.北京：人民卫生出版社，2003.8 103~106，194~206
