疏血通对大鼠脑出血后脑水肿的影响.doc
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疏血通对大鼠脑出血后脑水肿的影响,本文共计33页，16130字；摘要目的探讨应用疏血通进行抗凝血酶治疗对大鼠脑出血后早期脑水肿的影响及初步评估治疗的安全性。方法将Ⅳ型胶原酶定向注入大鼠左侧的尾壳核制作大鼠脑出血模型，并在注入胶原酶后4小时通过大鼠尾静脉注射疏血通进行抗凝血酶治疗，48小时后观察大鼠的脑组织的含水量、k＋、...
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疏血通对大鼠脑出血后脑水肿的影响
本文共计33页，16130字；
摘要
目的
探讨应用疏血通进行抗凝血酶治疗对大鼠脑出血后早期脑水肿的影响及初步评估治疗的安全性。
方法
将Ⅳ型胶原酶定向注入大鼠左侧的尾壳核制作大鼠脑出血模型，并在注入胶原酶后4小时通过大鼠尾静脉注射疏血通进行抗凝血酶治疗，48小时后观察大鼠的脑组织的含水量、K＋、Na＋的含量以及血肿体积来评价治疗对脑出血后脑水肿的影响及治疗的安全性。
关键词
脑出血，脑水肿，疏血通
Abstract
Objective
To observe the effect and safety of anti-thrombin treatment on ICH-induced early edema with Shuxuetong.
Method
We made the experimental intracerebral hemorrhage model in which Stereotaxic infusion of collagenase induced intracerebral hemorrhage. We infused Shuxuetong through tail venous 4 hours after infusion of collagenase. After 48 hours we observed the effect of Shuxuetong on brain water content, sodium and potassium content, and volume of hematoma.
目录
前言……………………………………………………1
摘要……………………………………………………2
正文……………………………………………………4
综述……………………………………………………19
M G……………………………………………………27
致谢……………………………………………………31
部分参考文献
1. Lee KR, Betz AL, Kim S, et al. The role of the coagulation cascade in brain edema formation after intracerebral hemorrhage. Acta Neurochir (Wien). 1996; 138(4): 396-401.
2. Xi G, Wagner KR, Keep RF, et al. Role of blood clot formation on early edema development after experimental intracerebral hemorrhage. Stroke. 1998 Dec; 29(12): 2580-2586.
3. Xi G, Hua Y, Bhasin RR, et al. Mechanisms of edema formation after intracerebral hemorrhage: effects of extravasated red blood cells on blood flow and blood-brain barrier integrity. Stroke. 2001, 32: 2932-2938.
4. Xi G, Keep RF, Hoff JT. Erythrocytes and delayed brain edema formation following intracerebral hemorrhage in rats. J Neurosurg. 1998, 89: 991-996.
本文共计33页，16130字；
摘要
目的
探讨应用疏血通进行抗凝血酶治疗对大鼠脑出血后早期脑水肿的影响及初步评估治疗的安全性。
方法
将Ⅳ型胶原酶定向注入大鼠左侧的尾壳核制作大鼠脑出血模型，并在注入胶原酶后4小时通过大鼠尾静脉注射疏血通进行抗凝血酶治疗，48小时后观察大鼠的脑组织的含水量、K＋、Na＋的含量以及血肿体积来评价治疗对脑出血后脑水肿的影响及治疗的安全性。
关键词
脑出血，脑水肿，疏血通
Abstract
Objective
To observe the effect and safety of anti-thrombin treatment on ICH-induced early edema with Shuxuetong.
Method
We made the experimental intracerebral hemorrhage model in which Stereotaxic infusion of collagenase induced intracerebral hemorrhage. We infused Shuxuetong through tail venous 4 hours after infusion of collagenase. After 48 hours we observed the effect of Shuxuetong on brain water content, sodium and potassium content, and volume of hematoma.
目录
前言……………………………………………………1
摘要……………………………………………………2
正文……………………………………………………4
综述……………………………………………………19
M G……………………………………………………27
致谢……………………………………………………31
部分参考文献
1. Lee KR, Betz AL, Kim S, et al. The role of the coagulation cascade in brain edema formation after intracerebral hemorrhage. Acta Neurochir (Wien). 1996; 138(4): 396-401.
2. Xi G, Wagner KR, Keep RF, et al. Role of blood clot formation on early edema development after experimental intracerebral hemorrhage. Stroke. 1998 Dec; 29(12): 2580-2586.
3. Xi G, Hua Y, Bhasin RR, et al. Mechanisms of edema formation after intracerebral hemorrhage: effects of extravasated red blood cells on blood flow and blood-brain barrier integrity. Stroke. 2001, 32: 2932-2938.
4. Xi G, Keep RF, Hoff JT. Erythrocytes and delayed brain edema formation following intracerebral hemorrhage in rats. J Neurosurg. 1998, 89: 991-996.
