活化诱导的细胞死亡与hiv感染.doc

活化诱导的细胞死亡与HIV感染

页数 7 字数 4184

摘要：活化诱导的细胞死亡(AICD)是HIV感染中引起大量T细胞凋亡的重要机制之一，因而备受人们的关注。多种HIV蛋白产物都对AICD的发生有不同的作用，而机体免疫系统的激活状态等因素也直接影响AICD的发生和发展方向，最终导致患者Th/Ts比例倒置及Kaposi肉瘤发生等多种临床特征的出现。IL-16、高效抗逆转录病毒疗法(HAART)等对AICD的过程有不同的影响，从而实现抑制HIV感染和控制病程的效果。

关键词：AICD,凋亡,HIV,AIDS,激活

Abstract: Activation-induced cell death(AICD) has drawn considerable interest as a key mechanism of T cells apoptosis during HIV infection. Different protein products of HIV show different effects on the process of AICD, and the activation state of the immune system itself may directly decide the initiation and progressing; which altogether lead to various clinical results, such as the reverse of Th/Ts ratio and the occurrence of Kaposi’s sarcoma. Through influencing the process AICD, IL-16、highly active antiretroviral therapy(HAART) may suppress replication and, subsequently, viral spread.
Key words: AICD; apoptosis; HIV; AIDS; activation

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