氨基糖苷类抗生素后效应及其临床意义.doc
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氨基糖苷类抗生素后效应及其临床意义,摘要:近年来,随着临床上大量抗生素的使用,以及学者通过对抗生素的深入研究,我们不难发现抗生素后效应( pae)已经越来越被人们所重视,并且在药效学上,作为一类新的且重要的参数。在病原微生物、抗菌药物、机体三者中扮演着重要的角色——为他们提供许多重要的信息。同时,它可以指导临床更加合理地...
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氨基糖苷类抗生素后效应及其临床意义
摘要:近年来,随着临床上大量抗生素的使用,以及学者通过对抗生素的深入研究,我们不难发现抗生素后效应( PAE)已经越来越被人们所重视,并且在药效学上,作为一类新的且重要的参数。在病原微生物、抗菌药物、机体三者中扮演着重要的角色——为他们提供许多重要的信息。同时,它可以指导临床更加合理地使用抗生素。临床上,有一类治疗感染性疾病不可或缺的抗生素,那就是氨基糖苷类抗生素。本文从氨基糖苷类抗生素后效应产生的机制、影响的因素,以及其联合用药时的后效应等出发,从而提出基于氨基糖苷类抗生素后效应的临床给药方案以及它的意义。
关键词:氨基糖苷类抗生素;后效应;临床意义
The Post Antibiotic Effect and Clinical Significance of Aminoglycoside Antibiotic
Abstract:In recent years, the research on the post antibiotic effect are becoming more and more deeply and widely as a large number of antibiotics using in clinical. The post-antibiotic effect as a new and important Pharmacokinetic parameters,provides more important information for the relationship of the bacteria,the body and antibiotics of the three. At the same time,it’s an important guidance for Clinical rational use of antibiotics. Aminoglycoside antibiotics is an important class of antibiotics on treatment of infectious diseases in the clinical.This article is going to talk about the mechanism of aminoglycoside antibiotic effect , influence factors, and the combined treatment .Finally, it puts forward the aminoglycoside antibiotic effect on clinical rational using antibiotics.
Keywords:Post antibiotic effect;Aminoglycoside antibiotics;Clinical significance
摘要:近年来,随着临床上大量抗生素的使用,以及学者通过对抗生素的深入研究,我们不难发现抗生素后效应( PAE)已经越来越被人们所重视,并且在药效学上,作为一类新的且重要的参数。在病原微生物、抗菌药物、机体三者中扮演着重要的角色——为他们提供许多重要的信息。同时,它可以指导临床更加合理地使用抗生素。临床上,有一类治疗感染性疾病不可或缺的抗生素,那就是氨基糖苷类抗生素。本文从氨基糖苷类抗生素后效应产生的机制、影响的因素,以及其联合用药时的后效应等出发,从而提出基于氨基糖苷类抗生素后效应的临床给药方案以及它的意义。
关键词:氨基糖苷类抗生素;后效应;临床意义
The Post Antibiotic Effect and Clinical Significance of Aminoglycoside Antibiotic
Abstract:In recent years, the research on the post antibiotic effect are becoming more and more deeply and widely as a large number of antibiotics using in clinical. The post-antibiotic effect as a new and important Pharmacokinetic parameters,provides more important information for the relationship of the bacteria,the body and antibiotics of the three. At the same time,it’s an important guidance for Clinical rational use of antibiotics. Aminoglycoside antibiotics is an important class of antibiotics on treatment of infectious diseases in the clinical.This article is going to talk about the mechanism of aminoglycoside antibiotic effect , influence factors, and the combined treatment .Finally, it puts forward the aminoglycoside antibiotic effect on clinical rational using antibiotics.
Keywords:Post antibiotic effect;Aminoglycoside antibiotics;Clinical significance