果糖冻干粉针、葡萄糖溶液与多烯磷脂酰胆碱注射液配伍后的微粒观察.doc

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果糖冻干粉针、葡萄糖溶液与多烯磷脂酰胆碱注射液配伍后的微粒观察,果糖冻干粉针、葡萄糖溶液与多烯磷脂酰胆碱注射液配伍的微粒观察目录前言(1)1、仪器和药品 (2)2、方法与结果 (2)2.1、不同稀释液与易善复的配伍前后变化 (2)3、讨论 (4)3.1、实验用水的影响 (4)3.2、ph值的影响(4)3.3、微粒的影响 (4)3.4、影响不溶性微粒的因素 (4)3.5、微粒数的观察...
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分类: 论文>药学/医学论文

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果糖冻干粉针、葡萄糖溶液与多烯磷脂酰胆碱注射液配伍的微粒观察


目 录

前言……………………………………………………………………………(1)
1、仪器和药品 ………………………………………………………………(2)
2、方法与结果 ………………………………………………………………(2)
2.1、不同稀释液与易善复的配伍前后变化 ………………………………(2)
3、讨论 ………………………………………………………………………(4)
3.1、实验用水的影响 ………………………………………………………(4)
3.2、pH值的影响……………………………………………………………(4)
3.3、微粒的影响 ……………………………………………………………(4)
3.4、影响不溶性微粒的因素 ………………………………………………(4)
3.5、微粒数的观察与比较 …………………………………………………(4)
3.6、实验过程中的误差分析 ………………………………………………(5)
3.7、实验结果建议 …………………………………………………………(5)
结束语…………………………………………………………………………(5)
致谢……………………………………………………………………………(5)
参考文献………………………………………………………………………(6)


  
摘要:目的 观察果糖冻干粉针、葡萄糖溶液分别与多烯磷脂酰胆碱注射液配伍前、后不溶性微粒的变化和配伍情况,为临床选择不同溶媒与多烯磷脂酰胆碱注射液配伍提供参考。方法 用pH计测定各溶液的pH,并按照“不溶性微粒检查法”,采用ZWF-J6激光注射液微粒分析仪检查微粒的变化。结果 各溶液配伍后pH值没有太大的变化,且溶液澄清,但多烯磷脂酰胆碱注射液与果糖冻干粉针配伍较多烯磷脂酰胆碱注射液与葡萄糖溶液配伍后的微粒数明显增加,但微粒数都未超过药典规定。结论 果糖冻干粉针可以与多烯磷脂酰胆碱注射液配伍,但要考虑对不溶性微粒数的控制。
关键词:果糖冻干粉针 葡萄糖注射液 多烯磷脂酰胆碱注射液 微粒观察

Abstract:Purpose To observe the change of insoluble particles of fructose for injection and glucose solution after compatibility with polyene phosphatidylcholine injection and to offer the reference of choosing a different solvent of polyene phosphatidylcholine injection for clinical practice. Methods To use the pH meter to determine the pH of each solution and to check the particles through the use of ZWF-J6 laser analyzer of particles of injection according to "Insoluble Particles Test". Results There is little change of pH after the compatibility of various solutions and each solution is clear, but more particles have been found significantly in fructose solution than glucose solution after compatibility with polyene phosphatidylcholine injection and none of them exceeds the criterion according to pharmacopoeia. Conclusion The compatibility of fructose for injection and polyene phosphatidylcholine injection is feasible, but the control of insoluble particles should be considered.
Keywords:Fructose; glucose; polyene phosphatidylcholine; particles