白藜芦醇乙酸酯的合成工艺研究.doc
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白藜芦醇乙酸酯的合成工艺研究,摘要：白藜芦醇,3,4’,5-三羟基二苯乙烯,是一种植物抗毒素,近年来,由于这种多酚化合物具有显著的抗氧化、抑菌等生物活性和对癌症、炎症、心血管疾病的治疗潜力,越来越多的科研队伍对白藜芦醇及其衍生物展开了如火如荼的研究。以乙酰氯、白藜芦醇为原料, 采用三乙胺为缚酸剂合成方法在碱性条件下制备白...
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白藜芦醇乙酸酯的合成工艺研究
摘要：白藜芦醇,3,4’,5-三羟基二苯乙烯,是一种植物抗毒素,近年来,由于这种多酚化合物具有显著的抗氧化、抑菌等生物活性和对癌症、炎症、心血管疾病的治疗潜力,越来越多的科研队伍对白藜芦醇及其衍生物展开了如火如荼的研究。以乙酰氯、白藜芦醇为原料, 采用三乙胺为缚酸剂合成方法在碱性条件下制备白藜芦醇乙酸酯, 期望寻找活性更高的药物。并通过实验得到了目标产物白藜芦醇乙酸酯,后处理简单方便, 产率达90. 1% 。产物经过薄层色谱等进行了表征。该合成方法可行, 并且后处理简单方便, 产率高。
Abstract : Resveratrol,3,4 ,5-trihydroxystilbene, is a phytoalexin found in grapes, Polygonum Cuspidatum and other plants. In recent years, this polyphenol has attracted the attention of researchers because of its remarkable therapeutic potential including chemoprevention of cancer, inflammation, cardiovascular diseases. In addition, reseveratrol shows antioxidant, antibacterial and antifungal activities. Using Acetyl Chloride and resveratrol as the starting materials to get the target compounds by the esterification reaction，in order to synthesize a new prodrug , resveratrol acetate . And a mutual prodrug resveratrol acetate was designed and synthesized. So a novel method for synthesis of resveratrol and resveratrol trinicotinate has been afforded.
中文关键词：白藜芦醇 白藜芦醇乙酸酯 合成
英文关键词：resveratrol; resveratrol acetate; synthesis
摘要：白藜芦醇,3,4’,5-三羟基二苯乙烯,是一种植物抗毒素,近年来,由于这种多酚化合物具有显著的抗氧化、抑菌等生物活性和对癌症、炎症、心血管疾病的治疗潜力,越来越多的科研队伍对白藜芦醇及其衍生物展开了如火如荼的研究。以乙酰氯、白藜芦醇为原料, 采用三乙胺为缚酸剂合成方法在碱性条件下制备白藜芦醇乙酸酯, 期望寻找活性更高的药物。并通过实验得到了目标产物白藜芦醇乙酸酯,后处理简单方便, 产率达90. 1% 。产物经过薄层色谱等进行了表征。该合成方法可行, 并且后处理简单方便, 产率高。
Abstract : Resveratrol,3,4 ,5-trihydroxystilbene, is a phytoalexin found in grapes, Polygonum Cuspidatum and other plants. In recent years, this polyphenol has attracted the attention of researchers because of its remarkable therapeutic potential including chemoprevention of cancer, inflammation, cardiovascular diseases. In addition, reseveratrol shows antioxidant, antibacterial and antifungal activities. Using Acetyl Chloride and resveratrol as the starting materials to get the target compounds by the esterification reaction，in order to synthesize a new prodrug , resveratrol acetate . And a mutual prodrug resveratrol acetate was designed and synthesized. So a novel method for synthesis of resveratrol and resveratrol trinicotinate has been afforded.
中文关键词：白藜芦醇 白藜芦醇乙酸酯 合成
英文关键词：resveratrol; resveratrol acetate; synthesis
