毕业设计-年产一百万十亿粘杆菌素发酵车间设计.rar

包括开题报告，中期报告，任务书，论文，cad图纸等整套作品

摘  要

依据于丽珠集团福州福兴医药有限公司的发酵车间实际情况，设计了平均效价为500000IU/ml，年产为一百万十亿（IU）粘杆菌素发酵车间。在设计中采用了机械搅拌通风式发酵罐、间歇流加法补糖和补氨及符合GMP制药车间作业规范。进行了：工艺设计、车间设计、车间图纸的绘制、生物反应器的设计及物料和能量衡算等。

关键词：粘杆菌素；发酵车间；设计。

Design a fermentative workshop of Colistin with annual production million billion (IU)

Abstract

According to the LiZhu group FuXing fuzhou pharmaceutical Co., LTD. of fermentation workshop actual situation，The average potency unit for design is 500000IU/ml，annual production million billion (IU) with colistin fermentative workshop. In the design use the mechanical ventilated motor fermentor、intermittent flow additive for sugar and ammonia water and in accordance with GMP pharmaceutical workshop working standard. The design specification contains:process design, shop drawings, workshop design drawing, biological reactor design and material and energy balance and so on.

Key words：Colistin; fermentative workshop；design.

目录

第1章  绪论

1.1 粘杆菌素工厂简介········································· 1

1.2 概况····················································· 1

1.3 课题意义及设计内容······································· 2

第2章  工艺设计

2.1 产品概述················································· 3

2.2 产品标准················································· 3

2.2.1 兽用质量标准··········································· 3

2.2.2  EP4质量标准··········································  3

2.2.3  原材料质量规格········································ 4

2.2.4  生产培养基配方········································ 5

2.2.5  GMP对发酵车间作业要求································· 5

2.2.5.1清洁卫生标准操作规程····························· 5

2.2.5.2 种子罐工序·········································· 6

2.2.5.3发酵罐工序··········································· 7

2.3 工艺流程设计············································· 10

2.3.1  工艺概述及原则········································ 10

2.3.2  操作流程··············································· 10

2.3.3  发酵工艺流程··········································· 11

2.3.4  操作工时与生产周·········································  11

2.3.5发酵工艺控制  ····································  11

2.3.6  生产工艺流程图···········································  11

2.3.7  培养工程一览表·········································  12

第3章 车间设计

3.1 菌种选育车间············································  13

3.2  配料车间···············································  13

3.3.1  发酵车间·············································  13

3.3.1.1  机械搅拌通风发酵罐·································· 13

3.3.1.2  蒸汽系统············································ 14

3.3.1.3  冷却系统··········································· 14

3.3.1.4  DCS控制中心·······································  15

3.4  发酵车间布置··········································  15

3.4.1  整体布置············································  15

3.4.2  平面布置············································  15

3.4.3  设备布置···········································   15

3.4.4  管道布置···········································   16

第4章  物料衡算及能量衡算

4.1 物料衡算··············································   17

4.2 能量衡算··············································  18

4.2.1  水平衡计算·········································  22

4.2.2  蒸汽耗量计算········································· 22

4.2.3  无菌压缩空气消耗量计算································· 23

第5章  设备选型及其计算

5.1 主要生产设备选型及其计算··································· 24

5.1.1 发酵罐设计············································  24

5.1.2 种子罐设计············································  28

5.2  空气分过滤器设计·········································  33

5.3  空气站空压机选择········································  34

5.3 设备清单··················································  34

5.4 总厂平面设计··············································  35

5.4.1  总平面设计的原则和要求·································  35

5.4.2  厂区组成与划分·········································· 36

5.4.3  总平面图的绘制········································  36

第6章   技术经济与概算

6.1 产品成本概算及经济效益分析··································  37

结论与展望······················································  38

致谢·······················································  39

参考文献···················································  40