药物代谢模型的自适应滑膜控制.doc
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药物代谢模型的自适应滑膜控制,1.2万字自己原创的毕业论文，仅在本站独家出售，重复率低，推荐下载使用摘 要 药物在体内经历吸收、分布、代谢和排泄等过程的处置，自始至终都处于动态变化之中，且药物的体内处置过程较为复杂，受到体内诸多因素的影响。房室模型分析是进行药物代谢动力学分析的一种经典的方法，它借助数学的原理和方法来系统...
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药物代谢模型的自适应滑膜控制
1.2万字
自己原创的毕业论文，仅在本站独家出售，重复率低，推荐下载使用
摘 要 药物在体内经历吸收、分布、代谢和排泄等过程的处置，自始至终都处于动态变化之中，且药物的体内处置过程较为复杂，受到体内诸多因素的影响。房室模型分析是进行药物代谢动力学分析的一种经典的方法，它借助数学的原理和方法来系统地阐明体内药量随时间而变化的规律性。利用房室模型可以建立药物在人体各个器官的转移模型，可以定量地描述药物体内过程的动态变化规律性。本课题研究的是己烯雌酚在人体各器官转移的房室模型。
自适应滑模变结构控制是滑模变结构控制与自适应控制的有机结合，是一种解决参数不确定或时变参数系统控制问题的一种新型控制策略。本文基于房室模型方法建立己烯雌酚数学模型，研究了己烯雌酚在各个房室之间转移速率未知的情况下自适应滑模控制的问题。通过理论分析和仿真实验，说明了自适应滑模控制的有效性。
关键词：药物代谢 房室模型 己烯雌酚 自适应控制 滑模控制
Adaptive Sliding-Mode Control for Drug Metabolism Model
Abstract Drug disposition through absorption,distribution, metabolism and excretion in vivo from first to last, are undergoing dynamic changes, and the disposition of drugs is complex, is affected by many factors in vivo.Compartmental model analysis is a method of classical analysis of pharmacokinetics, regularity of the mathematical principles and methods to systematically elucidate the in vivo dose vary with time. Using the compartmental model can build transfer model of drugs in the human body each organ, can quantitatively describe the dynamic change regularity in vivo drug. This paper is on the study of compartmental model transfer of diethylstilbestrol in various organs of the body.
Adaptive sliding mode variable structure control is sliding mode variable structure control and the combination of adaptive control, is a kind of solving the problem of uncertain or time-varying parameter system control parameters of a new type of control strategy. This article is based on atrioventricular model method to establish mathematical model of diethylstilbestrol diethylstilbestrol was studied between various atrioventricular transfer rate under the condition of unknown adaptive sliding mode control problem. Through the theoretical analysis and simulation experiment, show the effectiveness of the adaptive sliding mode control.
Keywords: drug metabolism atrioventricular model diethylstilbestrol adaptive control
sliding mode control
目 录
第一章 引言…….....................................................................................................…..........4
1.1 研究背景................................................................................................................…...4
1.2 研究现状................................................................................................................…...5
1.3 主要内容 ...........................................................................................................…...7
第二章 己烯雌酚房室模型的建立...........................................................…...........8
2.1 房室模型................................................................................................................…...8
2.2己烯雌酚房室模型..........................................................................................…........10
第三章 己烯雌酚数学模型的自适应变结构控制设计.......................…....13
3.1 自适应变结构控制..............................................................................................…..13
3.1.1基于自适应的系统辨识.......................................................................…........14
3.1.2 滑模变结构控制.......................................................................................…....15
3.2 己烯雌酚模型的自适应滑模控制….......................…..........................................17
3.3 仿真结果 ............................................................................................................…....20
3.4 结论................................................................................................................22
总结.............................................................................................................................................23
致 谢……...................................................................................................................................25
参考文献……...........................................................................................................................26
附录……......................................................................................................................................28
1.2万字
自己原创的毕业论文，仅在本站独家出售，重复率低，推荐下载使用
摘 要 药物在体内经历吸收、分布、代谢和排泄等过程的处置，自始至终都处于动态变化之中，且药物的体内处置过程较为复杂，受到体内诸多因素的影响。房室模型分析是进行药物代谢动力学分析的一种经典的方法，它借助数学的原理和方法来系统地阐明体内药量随时间而变化的规律性。利用房室模型可以建立药物在人体各个器官的转移模型，可以定量地描述药物体内过程的动态变化规律性。本课题研究的是己烯雌酚在人体各器官转移的房室模型。
自适应滑模变结构控制是滑模变结构控制与自适应控制的有机结合，是一种解决参数不确定或时变参数系统控制问题的一种新型控制策略。本文基于房室模型方法建立己烯雌酚数学模型，研究了己烯雌酚在各个房室之间转移速率未知的情况下自适应滑模控制的问题。通过理论分析和仿真实验，说明了自适应滑模控制的有效性。
关键词：药物代谢 房室模型 己烯雌酚 自适应控制 滑模控制
Adaptive Sliding-Mode Control for Drug Metabolism Model
Abstract Drug disposition through absorption,distribution, metabolism and excretion in vivo from first to last, are undergoing dynamic changes, and the disposition of drugs is complex, is affected by many factors in vivo.Compartmental model analysis is a method of classical analysis of pharmacokinetics, regularity of the mathematical principles and methods to systematically elucidate the in vivo dose vary with time. Using the compartmental model can build transfer model of drugs in the human body each organ, can quantitatively describe the dynamic change regularity in vivo drug. This paper is on the study of compartmental model transfer of diethylstilbestrol in various organs of the body.
Adaptive sliding mode variable structure control is sliding mode variable structure control and the combination of adaptive control, is a kind of solving the problem of uncertain or time-varying parameter system control parameters of a new type of control strategy. This article is based on atrioventricular model method to establish mathematical model of diethylstilbestrol diethylstilbestrol was studied between various atrioventricular transfer rate under the condition of unknown adaptive sliding mode control problem. Through the theoretical analysis and simulation experiment, show the effectiveness of the adaptive sliding mode control.
Keywords: drug metabolism atrioventricular model diethylstilbestrol adaptive control
sliding mode control
目 录
第一章 引言…….....................................................................................................…..........4
1.1 研究背景................................................................................................................…...4
1.2 研究现状................................................................................................................…...5
1.3 主要内容 ...........................................................................................................…...7
第二章 己烯雌酚房室模型的建立...........................................................…...........8
2.1 房室模型................................................................................................................…...8
2.2己烯雌酚房室模型..........................................................................................…........10
第三章 己烯雌酚数学模型的自适应变结构控制设计.......................…....13
3.1 自适应变结构控制..............................................................................................…..13
3.1.1基于自适应的系统辨识.......................................................................…........14
3.1.2 滑模变结构控制.......................................................................................…....15
3.2 己烯雌酚模型的自适应滑模控制….......................…..........................................17
3.3 仿真结果 ............................................................................................................…....20
3.4 结论................................................................................................................22
总结.............................................................................................................................................23
致 谢……...................................................................................................................................25
参考文献……...........................................................................................................................26
附录……......................................................................................................................................28
