病变二尖瓣的水利特性研究.doc

病变二尖瓣的水利特性研究

1.48万字
自己原创的毕业论文，仅在本站独家出售，重复率低，推荐下载使用

摘要 二尖瓣是人体心脏的重要瓣膜组织，二尖瓣脱垂是指二尖瓣叶（前叶、后叶或两叶）在心室收缩期脱入左心房（向左房侧膨出），伴或不伴有二尖瓣关闭不全二尖瓣反流，会造成左心室扩张以及左心室功能障碍，一般而言约有10-20%的人有这种现象，但是绝大部分的人都无症状，本身并无太大的的研究意义与必要,而二尖瓣腱索断裂几乎总是导致急性、常常是严重的二尖瓣返流,或使慢性二尖瓣返流急性恶化.所以研究二尖瓣腱索断裂的特性对于病态二尖瓣病因的检测以及临床修复手术具有十分重要的指导意义.而由于生理系统本身的复杂机制以及生物体检测的困难我们不得不利用电路模拟仿真进行量化分析[1]。而传统的电路模拟系统一般是用一个二极管串接一个线性或者非线性电阻这样的简单模型来模拟。这种方法主要是模拟血液的单向流动特性。但是却忽略了诸如血液回流.瓣膜物理特征等重要特性。本文则采用的是实验台控制水压模拟瓣膜两端压力变化进行水利实验,从而得到相对准确的二尖瓣特性曲线。
本文首先介绍了实验的一些背景资料如当前的研究成果以及对本次实验的指导意义。而后对整个实验的过程以及整个实验装置的调整进行了阐述和分析，对实验结果也进行了初步的处理,随后还将根据流体特性对结果进一步处理以得到更为准确的二尖瓣特性曲线。
本次实验的主要工作意义在于利用水流模拟血液流动,并且利用真实猪心二尖瓣进行实验,回避了电路模型对于瓣膜生物特性的仿真不完全,能够更准确的测量出液体通过腱索断裂二尖瓣时压力流量的变化,对于二尖瓣乃至整个左心血液循环系统的仿真建模有着重要指导作用。

关键词：病变二尖瓣 腱索断裂 房室压差 血液流量方向 二尖瓣的特性曲线

Study on Hydraulic characteristics of The Diseased Mitral
Abstract Mitral valve tissue is an important part of human heart , mitral valve prolapse is the mitral valve (anterior , posterior lobe or both lobes ) in ventricular systole off into the left atrium ( left atrial side bulging ) , with or without mitral regurgitation mitral regurgitation can cause left ventricular dilatation and left ventricular dysfunction , in general , about 10-20 % of people have this phenomenon, but most people are asymptomatic itself is not much research significance and necessary, and mitral valve chordae rupture almost always lead to acute , often severe mitral regurgitation , or to acute exacerbation of chronic mitral regurgitation , so research two mitral valve chordae rupture properties for the detection of pathological etiology and clinical mitral valve repair surgery has a very important significance . rather difficult due to the complex biological mechanisms and physiological detection system itself we had to use circuit simulation quantitative analysis . The traditional circuit simulation system is generally a diode in series with a linear or non-linear resistance of such a simple model to simulate . This method is to simulate the characteristics of one-way flow of blood . But it ignores the important features such as the backflow of blood . Valvular physical characteristics.
This paper adopts the bench hydraulic control valve simulation experiment ends of Water Conservancy pressure changes , resulting in relatively accurate mitral valve characteristic curve.This paper describes the experimental paper first introduces some background information such as the current research and guidance for this experiment . Then for several changes throughout the experiment and the adjustment of the entire experimental setup are described and analyzed , the experimental results have also been preliminary processing , fluid properties will then be further processed in accordance with the results to obtain more accurate mitral characteristic curve.
The main significance of this experiment is to use hydraulic simulation of blood flow , and use real pig heart mitral experiment avoided the circuit model for the biological characteristics of the valve ignored , can more accurately measure the liquid through the mitral chordae rupture changes in pressure and flow valve , the mitral valve for simulation modeling and the whole left heart circulatory system plays an important role in guiding .
Key words： Mitral valve disease Chordal rupture Atrioventricular pressure Blood flow direction Mitral valve characteristic curve

目 录
第一章 绪论 1
1.1 二尖瓣腱索断裂的研究历史及发展现状 1
1.1.1 二尖瓣腱索断裂研究的发展状况 1
1.1.2 心血管建模仿真技术的现况 1
1.2 课题研究的背景、主要内容及意义 2
1.2.1 课题研究的背景 2
1.2.2 课题的主要研究内容及意义 4
1.3 小结 4
第二章 经由二尖瓣的血液循环原理结构 5
2.1左心血液循环过程 5
2.2 二尖瓣的模型 6
2.3 模拟左心环境的实验装置整体设计 6
2.4 小结 7
第三章 实验装置设计及实验流程 8
3.1 实验总体设计 8
3.2静态实验装置搭建 8
3.3动态实验装置搭建 12
第四章 实验步骤 16
4.1实验准备及注意事项 16
4.1.1二尖瓣数据记录 16
4.1.2二尖瓣解剖流程 16
4.1.3 二尖瓣安装步骤 17
4.2 静态实验 18
4.2.1 静态正向实验过程 18
4.2.2 静态返流实验过程 19
4.3动态实验 20
4.4 小结和实验结果预测 21
第五章 实验结果及分析 22
5.1 实验设计 22
5.2 系统测试调试 22-..